Neutralization of Symptoms Using Progesterone

Neutralization of Multiple Symptoms Using Progesterone



Since l980, I have been using dilutions of antigens to neutralize symptoms in allergy patients. Traditional allergists use dilutions as weak as 1:100,000 (or 10-5), a smaller number of allergists (Otolaryngolists and Pan American Allergy Society members) regularly use dilutions of 1:1,000,000 (or 10-6). In my practice I have seen remarkable results using a wide range of dilutions.  The most effective and longest acting have been 10-5 and stronger.

Since l995, I have found many patients, particularly women, respond favorably to dilutions of the hormone Progesterone. Progesterone dilutions have been administered sublingually to hundreds of my patients as a routine screening methodology during their initial evaluation.

Over that past 2 years, we made digital video recordings of 350 patients recording their initial evaluation using different dilutions of Progesterone. The symptoms that have been addressed include neck pain, nasal congestion, eye irritation, throat pain, shortness of breath, headache, sinus pressure, ear pain, skin irritation, back pain, hip pain, upper and lower extremity pain. The patients were asked to evaluate their symptoms and place a numerical value on each symptom. They were asked to assess each symptom at the moment of testing on a scale of 0 to 10, with 10 being the worst discomfort of that type they have experienced and 0 being complete absence of symptoms.

Using this methodology, the patients have been given intradermal or sublingual dilutions of Progesterone as set out above. Within a few seconds after the application of the antigens the patients report that they can tell a difference in their symptoms. They report these changes anywhere from 10 to 30 seconds after the antigen is applied. There have been no side effects in any of the tests, nor in any of the patients previously treated with these antigens.

While the digital video recordings are dramatic illustrations of the patients’ perceived response to the antigens, they do not constitute scientific evidence of the effectiveness of the antigen in reducing symptoms nor do they provide scientific evidence of the speed with which the antigens seem to work. In order to demonstrate the effect of the antigen it is necessary to elicit objective scientific evidence of quantifiable changes in the subjects.

My first line of inquiry led me to nuclear radiology. It was thought that a scan of the brain might well provide the type of evidence needed for this application. However, the nuclear radiologist pointed out the enormous cost and significant exposure to radiation. He suggested the possibility of an electroencephalogram (EEG). Two patients were subsequently tested while an EEG was being recorded. A digital video recording was made recording both the EEG and the administration of the antigen.

In each case there was a clear indication of electrical change in the brain. The patients were set up and a baseline established. Then placebo drops of normal saline were administered sublingually to establish a normal response. Subsequently the Progesterone was administered and within one second the alpha wave amplitude increased by over 80%. This was done using a standard EEG.

We have also performed spirometry on 22 “severe” asthmatics and demonstrated pulmonary function changes similar to those reported by patients here.  Progesterone sublingual drops resulted in over 80% reduction in forced expiratory volume and/or peak expiratory flow.  Recently we have begun collecting data on Progesterone Antibodies (IgE, IgG and IgM) and have found that over 60% of the patients had out-of-range high levels of these antibodies.

These Progesterone Antibody levels can be ordered from most clinical pathology labs and cost about $100.00.  The local labs send this to Immunosciences  Lab at the address below:

Immunosciences Lab., Inc.

8693 Wilshire Blvd.,

Beverly Hills, CA 90211




  • Progesterone USP  50 mg./ml.
  • Sterile vials 5ml (Hollister-Stier, 3525 N. Regal, Spokane, WA)
  • Normal saline, without preservatives


Dilutions of progesterone are made into normal saline. This does not mix as the progesterone is in oil.  The best result is a fairly even suspension which can only be achieved by vigorous shaking at each stage of the initial; preparation and before using each vial.

The first dilution is made by adding 0.5 ml. of the progesterone to 4.5 ml. of normal saline. This results in a 1:10 dilution of the progesterone (Progesterone 10-1) which is labeled “PROG 1″.

Shake this vigorously and immediately withdraw 0.5 ml. From the vial marked “PROG 1″ and inject it into the next vial of 4.5 ml. normal saline. This results in a 1:100 dilution of the Progesterone (Progesterone 10-2) and the vial is labeled: “PROG 2.”

Shake this vigorously and immediately withdraw 0.5 ml. from the vial marked “PROG 2″ and inject it into the next vial of 4.5 ml. normal saline. This results in a 1:1000 dilution of the Progesterone (Progesterone 10-3) and the vial is labeled “PROG 3″.

Repeat this until you have five dilutions labeled “PROG 1″ through “PROG 5″.

  • Progesterone injectionUSP 50 mg./ml.
  • Prog 15 mg./ml.10-1
  • Prog 2.5 mg./ml.10-2
  • Prog 350 mcgm/ml.10-3
  • Prog 45 mcgm/ml.10-4
  • Prog 5.5 mcgm/ml.10-5

Always shake each vial vigorously before making dilutions and before each application.

The solutions diminish a wide variety of symptoms.  I am giving general numbers in the data table below.  All the exact numbers are better than those shown.  I cannot give the exact data as the material has been submitted to a medical journal for publication.


Neck Nose Eyes Throat HA Ear Skin Back Hips UpExt LExt SOB
# Patients 144 109 90 92 103 35 34 57 26 61 50 142
Responders 104 89 73 70 84 23 27 47 24 48 40 124
% Improvement in Responders >60% >60% >55% >60% >65% >20% >70% >70% >75% >75% >70% >65%
% Responders >70% >80% >80% >75% >80% >65% >75% >80% >90% >75% >75% >85%

My standard template lists the following symptoms:

1.  N.S
2.  P-5
3.  P-3
4.  P-1


  • Placebo.  Draw 0.10ml of normal saline into a 1cc syringe and squirt this under the tongue.
  • Prog 5.  Draw 0.10ml into a 1cc syringe and squirt this under the tongue.
  • Prog 3.  Draw 0.10ml into a 1cc syringe and squirt this under the tongue.
  • Prog 1.  Draw 0.10ml into a 1cc syringe and squirt this under the tongue.

Each patient is given the same sequence of drops.  After assessing all the symptoms and assigning a numerical value to each, the placebo drops are placed under the patient’s tongue and they are instructed not to swallow them for a count of five seconds.  Then they are asked to swallow the drops.  In about five or ten seconds I ask them if they can tell any change in any of their symptoms.  One must ask the patient about each area of symptoms.  The question is always put to the patient in the same way:  “Are your symptoms worse, unchanged, or better?”

This is designed to always give them the option of selecting “worse” or “unchanged” before “better”.  The purpose of this is to minimize the power of suggestion or “placebo” effect.  The patient is looking to the examiner for clues as to what to expect and we want to minimize the suggestion that their symptoms are expected to get better.

If all the symptoms disappear completely after the placebo, record this and do not proceed to any progesterone drops.  This has only happened once, in my experience.  A visiting physician was observing the protocol and the patient seemed quite impressed with his presence and interest.  I had never been able to get her pain below a three level in the past (she is on large amounts of Oxycontin for pain in her back and knees).  But, this time she smiled broadly and announced to us that the pain was…“completely gone!”…..

This is most unusual, but I frequently see a “placebo effect” that ranges from 10 to 50% relief of symptoms in about 20 to 30% of patients.  I think the average placebo effect in our last study was 18% across the board.

If at any point all the symptoms are relieved the tests are concluded and the patient is sent home with the same dilution of progesterone drops that relieved the symptoms.  They are instructed to use them as often as they need to as there is no therapeutic amount being delivered.  If the symptom relief does not last 12 to 24 hours, they need a vial one dilution stronger.

It is important to ask about each area of discomfort. In addition to our twelve standard categories we always ask about any other areas of discomfort the patient is experiencing at the moment of the questioning. The one area we do not list (and always ask about) is abdominal discomfort. This will include G.I. discomfort, endometriosis pain, interstitial cystitis, PMS cramps and pain and perineal itching or burning.

Patients must be questioned about each area. The patient is asked to grade the symptoms on a scale of one to ten. Zero is no symptoms at all and ten is the most intense discomfort the have experienced with this symptom. If the patient is asked to describe any symptoms they are experiencing at that moment, they will often omit symptoms in areas not included in their chief complaint.  If they come in with chest discomfort or shortness of breath, they might not mention their chronic back pain. Patients often acknowledge a present symptom when asked about an area specifically.

For more information contact:

Russell R. Roby, J.D., M.D., ACAAI, FCLM

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* This treatment is not approved by the FDA